This is… Psychedelic State(s) of America

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Psychedelics Unbounded
The Thing That Won’t Sit Still
By Jim Tate
From our friends at the Chronicles of Kykeon

Source: Chronicles of Kykeon on Substack
There’s a pattern that keeps repeating itself, like a fractal unfolding across decades. A government, a corporation, an organization, or a clinic decides psychedelics need managing. Papers are drafted, patents are filed, protocols get written but slowly and inevitably, the thing they’re trying to contain seeps through the walls.
Labs get raided, so the mushrooms fruit in closets. Patents get filed, so the mycelium spreads into common ground. Treatment centers standardize dosing, and someone in a forest somewhere is already having the experience the protocols were designed to prevent. It’s not rebellion, exactly. It’s more like watching water find its way downhill. You can build all the dams you want.
What makes psilocybin, LSD, mescaline, DMT and all the rest so persistently ungovernable isn’t their chemistry, it’s what they do. They take the self you’ve been carrying around like a fixed thing and show you it was actually pretty negotiable all along. They dissolve the edges you didn’t know you’d drawn. And once you’ve seen that happen, once you’ve felt the floor drop out from under consensus reality, something shifts in how you relate to authority. Not because you’re against it but because you’ve glimpsed how provisional it all is.
That’s the part no regulatory framework can touch. You can criminalize possession. You can medicalize administration. You can build a billion-dollar industry around ketamine clinics and MDMA therapy. But you can’t legislate what happens when someone realizes their sense of separateness was just a persistent habit. The experience itself exists in an interior, unverifiable, fundamentally private space that rules can’t reach.
The 1960s tried prohibition. Psychedelics were banned, research was shuttered, and the door slammed shut. Except the door was never actually solid. Underground chemists kept cooking. Deadheads kept dosing. Mazatec curanderas kept serving mushrooms in the mountains. The prohibition didn’t erase the substances; it just made them mythic. Outlaw status turned them into symbols of freedom, rebellion, and consciousness itself as contraband.
Now we’re in the medicalization wave dressed up as respectable and clinical. The psychedelic renaissance has PowerPoint decks and peer-reviewed protocols. But even here, there’s slippage. People keep reporting things the studies weren’t designed to measure reflecting encounters with entities, experiences of death and rebirth, and revelations the intake forms have no boxes for. The medicine refuses to stay in its lane.
Biotech companies are fully in the game now as they race to patent molecules and delivery mechanisms. The desire is to turn the unruly psychedelic experience into something scalable, repeatable, and investable. It’s a reasonable impulse because people are suffering. These compounds help so why not optimize? Because the compounds themselves seem to have other ideas. Users don’t describe psilocybin as a tool. They describe it as a teacher, with its own intelligence, its own agenda. Try to reduce that to a product and something essential evaporates. You can synthesize the molecule, but you can’t bottle the encounter. The experience keeps exceeding the container, reminding the clinician, the CEO, and even the patient that they’re not actually in charge here.
Maybe the real story is older than prohibition, older than commerce, older than the 1960s. Fungi have been breaking down rigid structures and redistributing their material for hundreds of millions of years. They resolve boundaries, recycle the fixed into the fertile, and make networks out of what looked like separate things.
Psychedelics work the same way, just on consciousness instead of dead wood. They break down mental rigidities and institutional certainties. They remove the barriers we build between self and others, sacred and profane, controllable and wild. Every attempt to fence them in becomes another demonstration of what they’re trying to teach: some forces don’t submit to domination. Some things are alive in ways that slip through the grid.
What if the lesson here isn’t about better laws or smarter business models? What if it’s about recognizing that psychedelics aren’t resources to be managed but relationships to be entered? That stewardship means learning to work with their nature instead of trying to override it.
Indigenous traditions understand this already. The medicine is respected, approached with ceremony, treated as a participant rather than a substance. There’s negotiation, reciprocity, humility. The modern impulse to control starts to look less like sophistication and more like a category error by trying to own something that can’t be owned, regulate something that exists primarily as transformation itself.
The mycelium doesn’t care about your permits. The vision doesn’t check if you’re authorized. The most alive, most transformative forces in the world have always moved through the cracks in our certainties, reminding us that what we can’t control might be exactly what we need most.
Editor’s Note: This article was originally published by our friends at the Chronicles of Kykeon over on Substack - be sure to support and subscribe!
PSA Media Partnership Spotlight: Work in Psychedelics
Tuesday Jobs Report: February 10th, 2026
✨Work in Psychedelics Presents… the Psychedelic Industry Job Roundup ✨
Tueday’s featured roles:
1️⃣ Insurance Accounts Receivable Specialist - Klarisana
📍 Westminster, Colorado
Manage insurance verification, authorizations, claims follow-up, and billing coordination within a ketamine-focused mental health clinic.
2️⃣ Authorization Coordinator - UC San Diego Health
📍 San Diego, California
Coordinate insurance authorizations, billing workflows, and claims resolution for interventional psychiatry services including TMS, ketamine or esketamine, and ECT.
3️⃣ Facilitation Program Lead - University of Wisconsin–Madison
📍 Madison, Wisconsin - Hybrid
Oversee facilitator operations, protocol fidelity, participant safety, and cross-functional coordination for psychedelic-assisted clinical trials.
4️⃣ Senior Product Manager - Journey Clinical
📍 New York City, New York - Hybrid
Lead product strategy, experimentation, and cross-functional execution across therapist and patient experiences in a ketamine-enabled healthtech platform.
5️⃣ Multiple Roles - Dutchie
📍 Remote
• Product Support Engineer - Resolve technical escalations, triage Jira issues, and partner with Product and Engineering as Voice of the Customer.
• Account Manager - Expand customer relationships, drive retention and revenue growth, and execute portfolio strategy.
• Customer Success Manager - Monitor account health, mitigate churn risk, and support dispensary outcomes across a 1-to-many customer model.
6️⃣ Partnerships Coordinator - Thesis
📍 New York, New York
Coordinate and grow strategic partnerships and collaborator relationships within a consumer mental wellness company operating in the psychedelic-adjacent space.
7️⃣ Multiple Roles - Definium Therapeutics
📍 Remote
• Vice President, Programs and Portfolio Office - Drive portfolio strategy, governance, and cross-functional execution across development programs.
• Associate Director, Medical Writing - Author regulatory documents and support global clinical communication and submissions.
• Senior Director, Clinical Data Management - Lead clinical data strategy, integrity, vendor oversight, and regulatory-ready quality.
• Senior Clinical Trial Manager - Manage site and vendor trial operations, compliance, and cross-functional delivery from protocol through reporting.
8️⃣ Accounting Manager - Vicente LLP
📍 Denver, Colorado
Oversee accounting operations, reporting, compliance, payroll, and financial controls within a professional services firm.
9️⃣ Senior Medical Science Liaison - Compass Pathways
📍 Remote - multiple territories available
Develop and manage territory-level scientific relationships across neuroscience and mental healthcare, lead compliant scientific exchange in treatment-resistant depression and PTSD, gather field insights to inform medical strategy, and support medical education, cross-functional collaboration, and future commercialization readiness within a phase 3–stage mental health biotech.
Full role details & applications: workinpsychedelics.com
📩 Questions? [email protected]
Note: All job listings are independently curated and written by Work In Psychedelics. While anyone/everyone is welcome to reference or share with credit and a link back. Automated scraping, wholesale reproduction, or republishing without attribution is discouraged.
All postings relate exclusively to legal job opportunities and educational materials within regulated jurisdictions and are shared for professional development only.
PSA Media Newswire Highlights

PSA Media Newswire Highlights

Psychedelics Today
From our friends at Psychedelics Today
Hosted by Joe Moore
Over at the Guardian
By David Shariatmadari

Psychedelic Brain Science
From our friends at Psychedelic Brain Science
Hosted Dr. Alaina Jaster

Talking Drugs
From our friends at Talking Drugs
By Ryan Hekseth
Until next time,
The Psychedelic State(s) of America Team


